Matt, Chris, and Jennifer Rider (our first ever guest host) discuss a pragmatic trial of smoking cessation, examine the pros and cons of surrogate endpoints, and Chris schools us all on horse dentistry.
Matt, Chris, and Don do their second ever live podcast, exploring a study on the effects of sleep on mortality, the gang discusses a proposal to change the definition of statistical significance, and Chris goes rogue and has three amazing and amusing articles.
Matt, Chris, and Don discuss a new treatment for lung cancer (immunotherapy), the gang discusses a large clinical trial that controversially changed its endpoint, and Chris dives into the world of linguistics (again).
Matt, Chris, and Don look at a drug company antidepressant trial in adolescents that was re-analyzed by different authors who came to different conclusions, the gang discusses the pre-registration movement in psychology, and Matt finds out what happens to all those unreported clinical trials.
Matt, Chris, and Don finally take on one of their own studies and see how it holds up, the gang discusses what to do when your study has flaws, and Chris tells us what happens if you don’t get funding as a junior faculty member.
Matt, Chris, and Don tackle a study on the effectiveness of opioids vs non-opioids for chronic pain, the gang discusses new NIH rules on how a clinical trial is defined, and Matt reads us some academic love poems.
Matt, Chris, and Don are joined by two faculty from the BUSPH Biostats Department to discuss a massive meta-analysis on the effectiveness of antidepressants, then we talk about the pros and cons of meta-analysis, and Don gives us some driving advice.
Matt, Chris, and Don weigh in on an area they finally have some expertise in (HIV) by reviewing a study of HIV prevention in Uganda, examine the difference between “efficacy” and “effectiveness,” and Matt gets dangerously close to a word we’re not allowed to say.
Matt, Chris, and Don discuss the paper that set off the MMR and autism controversy, dive deep into the peer review system, and Chris and Don leave Matt scratching more than his head with their Amazing and Amusing contributions.
Matt, Chris, and Don review a new study suggesting chocolate may reduce your risk for atrial fibrillation, discuss the difference between observational studies and randomized controlled trials and ask whether Usain Bolt is fast enough to cause a Doppler shift.